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Surgical intervention Trials Unit (SITU) at Oxford

The Surgical Intervention Trials Unit (SITU) consists of teams of surgical investigators, providing a training and development hub for surgical trialists within the UK. SITU is located in the Botnar Research Centre where project management support is currently provided in the delivery of two large multi-centre trials, whose areas of surgical interest are cardiac and transplant surgery.

The unit, co-directed by Professor Michael Douek (The Rosetrees and Royal College of Surgeons of England Director of SITU) and Professor David Beard (The Rosetrees and Royal College of Surgeons of England Director of SITU, NDORMS) will draw upon the considerable methodological and practical trials expertise in Oxford, including six accredited trial units, statistical, ethical, health economic, systematic review, clinical network resources and the IDEAL collaboration. 

SITU works as part of the Oxford Clinical Trials Research Unit (OCTRU) directed by Professors Duncan Richards and managed by Dr Vicki Barber, OCTRU is a UKCRC registered trials unit that provides substantial support from extensive quality assurance and regulatory affairs experience to database and randomisation services. Through this partnership, SITU aims to be a centre of excellence for the design and management of surgical trials, welcoming trials which aim to answer important problems in the UK and worldwide. 

SITU’s strategic aims for the future are to:

  • work with and encourage researchers in the design of randomised clinical trials using novel approaches for evaluating surgical interventions;
  • provide trials unit support in the coordination, management and delivery of innovative trials for researchers with surgical interest in all surgical specialties;
  • support translational research by the development of pilot studies evaluating new technology or interventions leading to randomised phase III/IV clinical trials;
  • provide expertise, training and development to researchers involved in surgical clinical trials from experienced researchers and clinical research trialists;
  • provide guidance and support to surgical specialist researchers to develop and conduct clinical trials in their area of expertise, ensuring trials are conducted to ICH GCP, and relevant legal and regulatory standards.

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